to attempt to validate these associations.
dence interval (CI) 0.57–1.26] to 0.86 (95% CI 0.57–1.28)
and for rs12143842 from 1.18 (95% CI 0.95–1.47) to 1.17
RESULTS (95% CI 0.93–1.45). When QT interval, heart rate (RR inter-
val) and QRS duration were subsequently added as continuous
Study subjects and genotyping
variables in the model, the HRs for rs12567209 and
Baseline characteristics for the study population, consisting of rs12143842 were 0.74 (95% CI 0.47–1.17) and 1.06 (95%本文来自辣.文,论-文·网原文请找腾讯752018766
all genotyped Rotterdam Study participants (n1/4 5974), and CI 0.82–1.35), respectively, (Table 2).
SCD cases are summarized in Table 1. During a mean of 10.4 To compare our results with the results from Kao et al.(18),
years of follow-up, 208 SCDs, 109 of which witnessed, were QT interval was also modeled as a categorical variable (quin-
identified. Successful genotype calls were made in 99.7% tiles). This showed similar results compared with analysis
(rs12143842)and99.8%(rs12567209)ofthesubjects,respect- including the linear QT variable for both rs12567209 (HR 1/4
ively.ThegenotypefrequenciesareinHardy–Weinbergequili- 0.73; 95% CI 0.46–1.16) and rs12143842 (HR 1/4 1.07; 95%
brium for both rs12143842 (T-allele frequency1/424.0%) and CI 0.84–1.36). Additional adjustment for myocardial infarc-
rs12567209 (A-allele frequency1/414.9%) with P1/4 0.72 and tion, diabetes, heart failure, hypertension, smoking and body
P1/4 0.85, respectively. The imputed genotype for rs16847548 mass index did not change the effect estimates (Table 2).
was available for all subjects. The imputation quality of this To account for potential measurement errors
hindi sms http://www.hindisms-hindi.com/ of the QT
SNP was very good with an observed/expected variance ratio interval, additional analyses were performed with exclusion 本文来自辣.文,论-文·网原文请找腾讯752018766
of0.993. of those subjects who showed a left or right bundle branch
For secondary analyses exploring the effect of a differential block, QRS duration over 120 ms or had prevalent atrial fibril-
outcome definition on established risk factors, the study lation. This did not change the results substantially (Table 2).
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