摘要：近几年来，绝大多数化学家们设计高效率，低成本的反应同时也很关注如何朝绿色化学的方向进行研究，减少对环境的破坏，α-氯代羰基化合物作为重要的有机合成中间体，其传统的反应制备过程往往反应速率慢，反应试剂多为有毒性的化学物质，这与当代绿色化学概念完全不符。本文以低毒，无害的甲醇作为溶剂高效的快速的发生氯代反应，整个实验过程本着绿色化学的理念进行开展，能保证反应快速氯代且高产的情况下无污染无公害。41572
本论文首先尝试了优化反应条件，使用苯乙酮作为底物，不断调整催化剂选择了低毒、廉价的强氧化性的氯代试剂三氯异氰尿酸（TCCA）3.5mmol参与反应，选择甲醇作为溶剂20mL，优化了TCCA与甲醇之间的比例，同时加入催化剂苄基三乙基氯化铵，优化反应时间、蒸馏时间，均保持在2h、调整反应温度、优化尝试在此反应条件上研究出绿色、快速、高效的一氯代化合物合成路线，且高产出具有高选择性的一氯代物，阻断副产物二氯代物的生成。之后本文继续探究醇类化合物参与的快速氯代反应普适性探索性，衍生到其他芳香族底物，结果表明：所得产率在80.5 %~92.9 %之间。本文实验方案接近绿色化学中“有效利用(最好可再生)原料，消除废物和避免使用有毒的和危险的试剂和溶剂。”这一特点。
毕业论文关键词： 绿色化学；有机合成；醇类化合物；一氯代苯乙酮
 Alcohol Compounds Participating Fast Chlorination Reaction
Abstract: Recently, most chemists tend to focus on the concept of green chemistry during their research as well as looking for efficient and low cost reaction, reducing damage to the environment. Alpha chlorinated carbonyl compounds, as a vital organic synthetic intermediate, has a relatively slower reaction process in tradition way, and its reaction reagent are mostly toxic, which is contrary to the idea of green chemistry. This research uses methanol, which is low-toxic and health, as the reagent to process efficient chlorination at room temperature. Not only to have rapid chlorine generation and productive reaction, the concept of green chemistry is carried out in this whole experiment to ensure pollution-free and nuisanceless.
  This paper attempted to optimize the reaction conditions first, used of phenyl ethyl ketone as substrate, continuoued adjustment of catalyst, and a low toxicity, inexpensive and strong oxidizing agent was selected to participate in the reaction of chloride reagent three chlorinated isocyanuric acid (TCCA) 3.5mmol participation in response, selected 20mL methanol as solvent, the ratio between TCCA and methanol was optimized, simultaneous addition of catalyst three benzyl triethyl ammonium chloride,optimization of reaction time and distillation time,are kept in 2H,adjusted reaction temperature, optimization attempted to study the synthesis route of a green, fast and efficient chlorine generation compound, and the high yield of a chlorine generation with high selectivity, Production of two chlorine generation by blocking the by-product. In this paper, we continued to explore the rapid chloride generation of alcohol compounds involved in the exploration, derived from other aromatic substrates, the results showed that: the yield percents was between 80.5%~92.9%. In this paper, the experimental approach is close to the green chemistry, "the effective use of (the best renewable) raw materials, eliminating of waste and avoiding the use of toxic and dangerous reagents and solvents."
Key words: Green chemistry; organic synthesis; alcohol compounds;One chlorine substituted phenyl ethyl ketone
 目  录
1 绪论    1
1.1 醇类化合物的各类应用    1
1.1.1 醇类化合物在有机合成的应用    1
1.1.1.1 作为有机合成中间体的醇类化合物    1 醇类化合物参与的快速氯代反应研究:http://www.751com.cn/huaxue/lunwen_41674.html