Many writers have written articles on the relationship between human and animals at home and abroad. In order to tell us we should adapt to the environment, and live in harmony with nature, Curley Dorothy Nye referred to naturalism in Modern American Literature, and Jack London’s view of nature fully expressed the call of the wild. Rubin stein pointed out the significance of the call of the wild and ecological problems which were caused by it in American Literature Root and Flower in 2001. Before Buck surrendered to the call of the wild, Buck did selfless dedication for Thornton and had the reforming spirit, reflecting the necessity of the harmonious coexistence of human and animal. Chen Guangming wrote A Mirror Refracted the Thought of Jack London-Discuss the Artistic Image in The Call of the Wild in1995, analyzed some experiences of Buck. Tan Yanping wrote Discuss the Artistic Image in The Call of the Wild in 2003, showing us the changes of Buck after getting along with different masters. This paper will analyze the relationship between human and animals in the novel in order to arouse people’s awareness so as to realize the harmony between human being, nature and society.