摘要：以4-苯氧基苯酚、氯乙酸甲酯为原料，以无水碳酸钾作碱性催化剂，N,N-二甲基甲酰胺(DMF)为溶剂，制备了中间体2-(4-苯氧基苯氧基)乙酸甲酯（Ⅰ）；将中间体（Ⅰ）分别与甲胺和二甲胺反应，得到产物N-甲基-2-(4-苯氧基苯氧基)乙酰胺（Ⅱ)和N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺（Ⅲ）。本文着重考察了反应时间、反应温度、物料投料比对中间产物（Ⅰ）和目的产物（Ⅱ）收率的影响。确定了2-(4-苯氧基苯氧基)乙酸甲酯合成工艺条件为：反应温度85℃；反应时间4.0h；物料投料比n(4-苯氧基苯酚）：n(氯乙酸甲酯)=1.00:1.15。在此条件下其收率为80%左右。N-甲基-2-(4-苯氧基苯氧基)乙酰胺合成工艺条件为：反应温度25℃；反应时间3.0h；物料投料比n[2-(4-苯氧基苯氧基）乙酸甲酯]：n(甲胺)=1.0:1.3。在此条件下，其收率为89%左右。经IR和1H-NMR表征，产物为N-甲基-2-(4-苯氧基苯氧基)乙酰胺（Ⅱ）和N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺(Ⅲ）。41174
毕业论文关键词：氯乙酸甲酯；4-苯氧基苯酚；2-(4-苯氧基苯氧基)乙酸甲酯； N-甲基-2-(4-苯氧基苯氧基)乙酰胺；N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺
TheSynthesis and Characterization of N-alkyl-2-phenoxyacetamide
Abstract: 2-(4-phenoxyphenoxy)acetate(Ⅰ)was synthesized from methyl chloroacetate
and 4-Phenoxyphenol in fixed temperature and react several hours, add potassium-carbonate as catalyst and N,N-dimethyl formamide as organic impregnant. Then review the inf-
luence of different react time, then the intermediates (Ⅰ) reaction with methylamine and dimethylamine respectively.Lastly,we wouldget the product of N-methyl-2-(4-phenoxyphenoxy)acetamide(Ⅱ)andN,N-dimethyl-2-(4-phenoxyphenoxy)acetamide (Ⅲ).The optim-
um reaction conditions of 2-(4-phenoxyphenoxy)acetate(Ⅰ)werefollows: temperature85℃, reactiontime 4.0h,n(4-Phenmethyl2oxyphenol):n(methyl chloroacetate )=1.00:1.15.
Yieldof methyl2-(4-phenoxyphenoxy)acetatewas above 80%;and the optimum reaction-conditions of N-methyl-2-(4-phenoxyphenoxy)acetamidewere separated as follows:temper-
ature 25℃, reaction time3.0h,n[methyl 2-(4-phenoxyphenoxy)acetate] ：n(methylamine)=1.0:1.3.Yieldof N-methyl-2-(4-phenoxyphenoxy)acetamidewas above 89%; By IR,1H-NMR and elemental analysis were characterized that it wereN-methyl-2-(4-phenoxypheno-
xy)acetamide(Ⅱ)andN,N-dimethyl-2-(4-phenoxyphenoxy)acetamide (Ⅲ).
Keywords:methylchloroacetate;4-phenoxyphenol;2-(4-phenoxyphenoxy)acetate;
N-methyl-2-(4-phenoxyphenoxy)acetamide;N,N-dimethyl-2-(4-phenoxyphenoxy)acetamide
目录
1 绪论 1
1.1除草剂国内外研究现状与水平 1
1.2农药发展趋势 4
1.2.1新农药创制方法 4
1.2.2世界农药市场及特点 4
1.3文献查阅、调研情况 5
1.3.1 酰胺类化合物概述 5
1.3.2 苯氧乙酰胺类的合成方法 7
1.4 本课题研究的内容及分析 9
1.4.1 本课题研究内容 9
2实验部分 12
2.1实验仪器与试剂 12
2.1.1 实验仪器 12
2.1.2 试剂及其物性常数 13
2.2产物的制备 13
2.2.1 2-(4-苯氧基苯氧基)乙酸甲酯的制备 13
2.2.2 N-甲基-2-(4-苯氧基苯氧基)乙酰胺的制备 13
2.2.3 N,N-二甲基-2-(4-苯氧基苯氧基)乙酰胺的制备 14
3结果与讨论 15
3.12-(4-苯氧基苯氧基)乙酸甲酯的制备 15
3.1.1 反应时间对2-(4-苯氧基苯氧基)乙酸甲酯收率的影响 15 N-烷基苯氧乙酰胺的合成及表征:http://www.751com.cn/huaxue/lunwen_41151.html