摘要： 碳酸钙作为典型的生物矿物和无机材料，在医疗、环境及工业中应用极其广泛。碳酸钙有三个多晶型结构：方解石(Calcite)，文石(Aragonite)以及球霰石(Vaterite)。对于纳米碳酸钙的密度小、比表面积大、安全性好、价格低廉等特点，其聚合物复合材料的制备和性能研究备受关注，特别是球状Vaterite。由于Vaterite的稳定性特别差，所以用其作为模板很容易能制成其他材料，其制备出的材料也颇受青睐，被广泛应用。本论文对碳酸钙纳米结构材料的药物传输性能进行了研究。系统研究了根据反应温度、反应方式的不同以及是否添加高分子溶液等手段，制得不同形貌、比表面积的Vaterite，并应用XRD、扫描电镜、透射电镜等的检测仪器确定其各方面的性能。最后利用得到的各种形貌Vaterite进行药物的吸附与解吸附实验，考察其在药剂学上的应用前景。20600
毕业论文关键词：碳酸钙；球霰石；载药；释放
Drug transmission performance research on calcium carbonate nanostructure materials
Abstract：As a typical mineral inorganic material, calcium carbonate is widely used in medical, environmental and industrial. Calcium carbonate has three polycrystalline structure：Calcite, Aragonite and Vaterite. For the characteristic of small density, large specific surface area, good security and lower price, the researches on preparation and properties of calcium carbonate polymer composites are high-profile, especially spherical Vaterite. Vaterite is easily used to make other materials because of the poor stability, which are quite popular and widely used. Drug transmission performance research on calcium carbonate nanostructure materials was studied in the paper. According to the different methods of reaction temperature, reaction means and whether to add high molecular materials, Vaterite has been made with different morphology and specific surface area. Properties can be confirmed by all kinds of advanced testing instruments, for example, XRD, BET, etc. Finally, the various morphology Vaterite was applied to medicine carrying and drug release to review its application prospect in medicine.
Key Words：Calcium carbonate；Vaterite；Medicine carrying；Drug release  
目 录
1 研究背景    1
1.1 碳酸钙药物的研究意义及简介    1
1.2 Vaterite的制备方法    1
1.2.1 半连续实验法    1
1.2.2 加入表面活性剂法    2
1.2.3气相沉积法    3
1.2.4模板法    3
1.3纳米CaCO3的应用    4
1.3.1 SiO2空心微球的制备    4
1.3.2合成纳米羟基磷灰石(HA)作为药物载体    4
1.3.3制备雷公藤红素缓释固体分散体    5
1.3.4复合材料的制备    5
1.3.5纳米CaCO3肠溶生物黏附片(NCaEBT)的制备    5
1.4 本课题研究的意义及思路    6
2 实验流程    7
2.1 合成Vaterite及研究其药物传输性流程    7
3 实验与材料    7
3.1 实验材料    7
3.1.1 主要试剂    7
3.1.2 主要仪器    8
3.2 实验与讨论    8
3.2.1 不加高分子材料PSS    9
3.2.2 加高分子材料PSS（聚苯乙烯磺酸钠，Mw=70000，ppm=10000）    11
3.2.3 XRD的测定    11
3.2.4扫描电镜(SEM)检测    23
3.2.5 BET检测    26
3.2.6 载药实验    27
3.2.7 药物解析附实验    28
4 总结与展望    30
致谢    31
参考文献    32 碳酸钙纳米结构材料的药物传输性能研究:http://www.751com.cn/yixue/lunwen_12575.html