（三）Typical equipment
According to the process calculation, the heat transfer area of the reaction equipment t can be known, Thereby determining reaction parameters and reactors. And according to the design requirements and actual production conditions to develop a reasonable production route. When calculating the typical equipment, the choice is the appropriate reaction still as the reaction vessel. At the same time should consider the form of reaction to adapt to the layout of the plant. Considering the production operation, installation, maintenance, safety and other factors, According to process requirements determine the location of the device. Taking into account the tidy and beautiful, and easy to management, to ensure the rationality and safety of the process.
（四）Non-process consideration
In addition to process design we should also consider many issues. Such as: civil engineering design and waste discharge. Civil engineering should consider the overall layout, but also should consider buildings in accordance with corporate image, pay attention to the work environment, etc. The most important attention should be paid to fire, waterproof and sanitation issues. In the production to take into account the safety of employees, to reserve the evacuation passageway and so on.
Key words: ethamhutol; d-2-amino-1-butanol;anti-TB drugs;synthesis;process design
目录
1 绪论    1
2 文献综述    1
2.1 乙胺丁醇介绍    1
2.1.1 乙胺丁醇介绍    1
2.1.2 乙胺丁醇的物性数据    1
2.1.3 乙胺丁醇合成方法综述    2
2.1.4 乙胺丁醇关键中间体d-2-氨基丁醇的合成    2
2.2 d-2-氨基丁醇与1 ,2-二氯乙烷合成乙胺丁醇    3
2.3 工业发展趋势    3
3 设计方案的论证    3
3.1 原料路线的选择    3
3.2 生产方法的可行性    4
3.3 生产规模的确定    4
4 工艺计算    5
4.1 生产流程    5
4.1.1 工艺流程岗位操作    6
4.2 物料衡算（ 100kg/日产）    7
4.2.1 缩合过程    7
4.2.2 成盐过程    12
4.2.3 碱化过程    15
4.2.4 乙醇回收过程    19
5 热量衡算    21
5.1 化学反应热    21
5.1.1 根据卡拉兹公式估算燃烧热ΔHC    21
5.1.2 计算（d—A）HCl的生成热ΔHf    21
5.1.3 计算d—A与二氯乙烷在20℃反应的反应热ΔHr*    22
5.1.4 估算Cp，求出ΔH1、ΔH2、ΔH3、ΔH4    22
5.2 其他反应热    25
6 设备选型    26
6.1 贮槽    26
6.2 反应器    27
7 工艺设备选型与设计计算    30
7.1 设备选型及传热面积考察    30
7.1.1 精制成盐锅传热面积校核    30
7.1.2 二氯甲烷冷凝器校核    33
7.1.3 d-a冷凝器的校核    35
7.2 设备一览表    37
8 结论    38
致谢    39
参考文献    40
附录    41
1 绪论
目前由结核病所引起的传染病以高增长率高传染率已成为全世界共同关注的人类健康问题。据报道我国目前结核病毒携带人数位居全国传染病携带人数前列，由于目前研究成果没有取得良好的进展。导致近几十年没有对抗结核病毒有明显疗效的药物出现[1]，结核病毒在人体内不能得到很好地控制，现在临床用药不能及时治疗结核病主要在其病毒在人体内的持留性和由于变异而产生的耐药性[2]，由于传染人数的增加，病毒的不断变异，加之没有很好的治疗方案。导致各大科研机构和医药企业加大了对新药的研究。但在短时间内没有很好地治疗方案，使患者在治疗的经济费用上和精神上饱受折磨。严峻的耐药形势要求加速新型抗结核药物的研究开发。 抗结核原料药生产车间工艺设计+CAD图纸+答辩PPT(2):http://www.751com.cn/huaxue/lunwen_26371.html