国内利用超连续谱作为OCT光源的研究较少,起步也较晚。2009年,天津大学精密仪器与光电工程学院郭以平等人利用亚皮秒脉冲光源抽运由不同特性光纤级联而成的混合非线性光纤来产生超连续谱,得到1300nm处3dB谱宽为140.6nm的宽带光谱。用此宽带光源作为光学相干层析系统光源,可以在生物体探测窗口约1300nm处达到小于4.1μm的纵向分辨率[11]。
综述:上述详实的文献充分表明了OCT技术在生物医学应用中的重要性,并且从各个方面对OCT技术的发展与应用做了分析研究。薛玲玲、王新宇等人最先概述了OCT在生物医学上的应用。刘伟、姜宇等研究了OCT的工作原理。钟会清、王淑霞等人研究了OCT在特定领域的应用。本文将在结合前人研究的基础上,根据目前OCT的发展与应用情况,对OCT的发展、原理及生物医学上的应用进行研究。
参考文献
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[2]I. Hartl, X. D. Li, C. Chudoba et al.. Ultrahigh-resolution optical coherence tomography using continuum generation in an air-silica microstructure optical fiber[J]. OPTICS LETTERS,2001,26(9):608-610.
[3]B. Povazay, K. Bizheva, A. Unterhuber et al.. Submicrometer axial resolution optical coherence tomography[J]. OPTICS LETTERS,2002,27(20):1800-1802.
[4]N. Nishizawa, Y. Chen, P. Hsiung et al.. Real-time, ultrahigh-resolution, optical coherence tomography with an all-fiber, femtosecond fiber laser continuum at 1.5 μm[J]. OPTICS LETTERS,2004,29(24):2846-2848.
[5]Yimin Wang, Ivan Tomov, J. Stuart Nelson et al.. Low-noise broadband light generation from optical fibers for use in high-resolution optical coherence tomography[J]. J. Opt. Soc. Am. A ,2005,22(8):1492-1499.
[6]Hui Wang,Andrew M. Rollins. Optimization of dual-band continuum light source forultrahigh-resolution optical coherence tomography[J]. APPLIED OPTICS,2007,46(10):1787-1794.
[7]HaohuaTu, Daniel L. Marks, Yee Lin Koh et al.. Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography[J]. OPTICS LETTERS,32(14):2037-2039.
[8]M. C. Stumpf, S. C. Zeller, A. Schlatter et al.. Compact Er:Yb:glass-laser-basedsupercontinuum source for high-resolution optical coherence tomography[J]. OPTICS EXPRESS,2008,16(14):10572-10579.
[9]K. Kieu, J. Klein, A. Evans et al. Ultrahigh resolution all-reflective OCT system with a compact fiber-based supercontinuum source[J].2011,CLEO.
[10]S. Ishida, N. Nishizawa. Quantitative comparison of wavelength dependence on penetration depth and imaging contrast for ultrahigh-resolution optical coherence tomography using supercontinuum sources at five wavelength regions[J]. Proc. of SPIE,2012,8213:821330-1-821330-6.
[11]郭以平,王肇颖,贾东方等.用于光学相干层析的超连续光纤光源研究[J].激光与光电子学进展,2009,12:124-128.
[12] http://www.thorlabschina.cn/NewGroupPage9.cfm?objectgroup_id=4406
[13] 贾亚青. 光学相干层析成像的实验研究与理论模拟[D]. 南开大学, 2007. DOI:10.7666/d.y1176794.
[14] JM. S, KM. Y, SH. X. Differential absorption imaging with optical coherence tomography[J]. Journal of the Optical Society of America A, 1998, 15(9):2288-2296.
[15] AJ L. Inserting a cyclic prefix using Arrayed-Waveguide Grating Routers in all-optical OFDM transmitters.[J]. Optics Express, 2012, 20(9):9925-9939.
[16] S.H.Yun, G J.Teazlley,B.E.Bouma,B.H.Park,and J.F de Boer,High-speed
spectral-domain optical coherence tomography at 1.3 μm wavelength[J],Opt.Express,2003,11:3598-3604.
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