摘要：己二酸单甲酯类是广泛使用的一类抑菌剂，具有杀菌谱广、对其他生物毒性低、环境相容性好等优点，但其水溶性差，在使用过程中易出现分层，极大地影响其使用效果。抑菌剂在油和水中的溶解度，直接影响其抑菌效果。新型抑菌剂的设计原则是要设计出油溶性小而水溶性大的抑菌剂。季铵盐抑菌剂水溶性和抑菌活性较好，这类抑菌剂的抑菌作用随季铵盐类结构变化的一般规律是：随着烷基链的增长，抑菌能力增强；但到一定长度，抑菌力反而下降。己二酸单甲酯是重要的医药中间体，是人工合成五子丙素和五子丁酯的重要中间产物，同时己二酸单甲酯也是一种重要的新型药物，随着人们对新型药物研究的不断深入，己二酸单甲酯将受到人们更多地关注。因此，合成己二酸单甲酯具有重要的理论意义和现实价值。本实验是采用己二酸与甲醇在浓硫酸的催化条件下得到己二酸单甲酯和己二酸二甲酯，再进行分离。27891
毕业论文关键词：己二酸单甲酯；己二酸；甲醇；浓硫酸；己二酸二甲酯
The synthesis of adipic acid methyl single study
Abstract: Adipic acid monomethyl ester class is a class of widely used antibacterial agent with bactericidal broad spectrum of other biological low toxicity and good environmental compatibility, but its poor water solubility, in the course prone to delamination, greatly affect its results. Bacteriostatic agent solubility in oil and water, direct impact on its antibacterial effects. The new design principles bacteriostatic agent is to design a small oil-soluble and water-soluble antibacterial agent big. A water-soluble quaternary ammonium antibacterial agents and antibacterial activity is better, the general rules of such antibacterial agent with bacteriostatic quaternary ammonium salts structural changes are: With the growth of alkyl chains, antimicrobial capacity enhancement; but to a certain length, antibacterial force decreased. Adipic acid monomethyl ester is an important pharmaceutical intermediates, is a synthetic Schizandrin C and Schisandra butyl important intermediate products, while adipic acid monomethyl ester is also an important new drug, as people new drug research the deepening, Adipic acid monomethyl ester class will be people pay more attention. Thus, adipic acid monomethyl ester synthesis has important reason.On the significance and practical value. This experiment is the use of adipic acid and methanol to give adipic acid monomethyl ester and adipic acid dimethyl ester under catalytic conditions in concentrated sulfuric acid, and then separated.
Key Words: Single adipic acid methyl ester; adipic acid; methanol; concentrated sulfuric acid; adipic acid dimethyl ester
目 录
1 前言    1
1.1 酯的介绍    1
1.2 酯的分类    1
1.2.1 单甘酯    1
1.2.2 偏苯三酸酯    1
1.2.3 邻苯二甲酸酯    1
1.2.4 季戊四醇油酸酯    2
1.3 酯的物理性质    2
1.4酯的化学性质    2
1.5酯的作用    2
2文献综述与方案论证    5
2.1文献综述    5
2.1.1 双酯类化合物的合成    5
2.1.2 单酯类化合物的合成    7
2.2合成己二酸单甲酯的用料    10
2.3 方案论证    14
2.3.1设计合成理念    14
2.3.2 合成己二酸单甲酯的理论方法    14
2.3.3 本课题研究主要内容    14
2.3.4 合成单酯所需解决的问题    15
3 实验部分    16
3.1 实验仪器与试剂    16
3.1.1 实验仪器    16 己二酸与甲醇在浓硫酸的催化下己二酸单甲酯的制备:http://www.751com.cn/yixue/lunwen_22541.html