设计总说明叶酸，又被称作文生素M；文生素Bc；文生素B9。它是一种淡黄色物质，溶于热水，也可溶于吡啶。如果缺乏叶酸会引起骨髓巨红细胞成熟受损，也可能巨红细胞贫血，还伴有白血球减少症，又可能导致妊娠中毒、早产、产后出血等多种疾病。叶酸主要分布在动物肝脏,绿叶蔬菜和微生物中。目前，叶酸的生产主要是化学合成，使用化学合成提取叶酸作为药物补充尚存在一些问题。正因为如此，发酵法生物合成的叶酸片市场潜力巨大，叶酸的车间生产工艺也显得尤为重要。33628
叶酸的合成工艺有几种方法，本设计最终采用工业化可行性和可操作性最大的通过对氨基苯甲酰谷氨酸，三氨基嘧啶硫酸盐，三氯丙酮及焦硫酸钠来合成叶酸。且以此工艺路线为基准设计工业生产过程。
采用现在市场中方便易得的工艺生产所需的原料，确定物料来源、价格和规格等，确定每种原料及最终成品的物性数据等。将对氨基苯甲酰谷氨酸，三氨基嘧啶硫酸盐，三氯丙酮及焦硫酸钠，合成反应时间控制在2小时且温度控制在50-60℃等，并利用叶酸的工艺研究中的确定的最佳工艺参数：进行物料和能量衡算。进而根据能量衡算确定生产过程使用的设备型号。
根据国家对药物企业生产的一系列要求，开发并设计适用于实际生产的工艺流程和设备布置图。
毕业论文关键词：叶酸；对氨基苯甲酰谷氨酸；工业生产；
 Design Specification
Folic acid is also known as vitamin M; vitamin Bc; vitamin B9.It is a light yellow substance, slightly soluble in hot water, soluble in pyridine. Lack of folic acid can induce megakaryocyte erythroid maturation is impaired, macrocytic anemia, accompanied by white blood cells to reduce disease, may also cause gestosis, premature delivery, postpartum hemorrhage and other diseases, folic acid is mainly distributed in animal liver, green leafy vegetables and microorganisms. At present, the production of folic acid is mainly chemical synthesis, chemical synthesis of folic acid as the drug supplement there are some problems. Therefore, the production of folic acid tablets in the fermentation process has great potential, and the workshop production technology is also important..
Synthesis of folic acid several mature laboratory synthesis method. this design finally adopted industrial feasibility and operation of the largest by amino benzoyl glutamic acid and three aminopyrimidine sulfate and three chlorine acetone and sodium pyrosulfate to folic acid synthesis. And this process to benchmark development into practical industrial production process.
The raw materials, the price and the specifications of the materials used in the process of production are convenient, and the material properties of every raw material and the final product are determined.The amino benzoyl glutamic acid and three aminopyrimidine sulfate, reaction time of 3 chloro acetone and sodium pyrosulfate control in 2 hours and the temperature control in 50 to 60 , and the use of folic acid in the process of research of the determination of the optimal process parameters: material and energy balance. And then, according to energy balance, the equipment used in the process of production is determined.
According to the national production of drug companies, a series of requirements, development and design for the actual production process and equipment layout plan.
Keywords: folic acid; P-Amino-benzoyl glutamic acid; industrial production
目  录
设计总说明Ⅰ
Design specificationⅡ
目录 Ⅲ
1.    引言1
1.1 选题的背景1
1.2 本工艺设计的意义1
1.3 生产叶酸的目的2
1.3.1叶酸的生理功能2
1.3.2 叶酸的吸收代谢2
1.3.3 叶酸的需求量2
1.3.4叶酸失调3
1.4 发展趋势3 年产600吨叶酸车间工艺设计+CAD图纸:http://www.751com.cn/yixue/lunwen_30814.html