摘要当今世界，糖基作为生物体内所必须的结构，具有广泛地的生物活性，是很多药物的先导结构，而噁二唑也是最近年来人们研究最热门的杂环化合物之一，它具有调节植物生长、除草、灭菌、杀虫、杀螨、消炎、抗癌、抗惊厥以及降血脂等非常重要的生物和生理活性。鉴于杂环化合物在人们生产生活中的重大作用，越来越多的农药及药物研发者将目光投向了杂环衍生物的合成研发。因此杂环化合物在近几十年来发展十分迅速。经过不断的研究，人们发现将两种具有不同生物活性的分子片段以一定的手段接到同一个分子中能够明显改善生成物的生物活性，糖基化合物与杂环化合物的结合，能实现不同生物活性的加合，因此，杂环糖基化合物的合成研究是杂环衍生物合成的一个重要的发展方向。在论文中，我们选用葡萄糖和尼泊尔金甲酯等作为起始原料，经过一系列的合成反应，最后环合生成糖基噁二唑化合物，经质谱、红外光谱、核磁共振谱确定它们的结构。47819

Recent years, carbohylrate as the necessary structure in living things, contain a lot of biological activities. They are the leading structure of many medicines. At the same time, since oxadiazoles has biological and physiological activities of plant growth regulation, weeding, insecticidal, acaricidal, sterilization, anti-inflammatory, anticancer, anticonvulsant and reducing blood fat, they become very popular in the field of heterocyclic compounds study. As heterocyclic compounds play a important role in people’s lifes, many researchers show great interest in them. As a consequence , in the recent years heterocyclic compounds are developing quickly . Then, people found that combining two different bioactive molecular fragments to the same molecules by a certain means can significantly improve its biological activity. Combining aldoses with heterocyclic compounds can realize the addition of different biological activities. So it become a important direction of further study. In the paper, we choose nepal methyl ester as the starting，after a series of reactions,the by MS, IR, 1H-NMR .

毕业论文关键词：糖基；噁二唑，杂环化合物

Keywords: glycosyl group; oxadiazoles; heterocyclic compound

目  录

1 引言 4

1.1 含糖基噁二唑衍生物的研究背景 4

1.2 含糖基噁二唑衍生物研究的意义 4

1.3 糖基化合物的合成与发展研究 4

1.4 噁二唑衍生物的合成与发展研究 8

1.5 主要研究内容 12

2 实验部分 12

2.1 实验试剂和实验仪器 12

2.1.1 仪器 12

2.1.2 试剂 12

2.2 实验设计路线 13

2.3 结果与讨论 14

2.3.1 溶剂对全乙酰溴代葡萄糖与尼泊尔金甲酯反应产率的影响 14

2.3.2 催化剂对全乙酰溴代葡萄糖与尼泊尔金甲酯反应产率的影响 糖基含氮杂环的合成方法研究:http://www.751com.cn/yixue/lunwen_50057.html