316L不锈钢片导电复合水凝胶及其药物释放

摘要本文选用316L不锈钢片为负载导电水凝胶的基底，首先制备掺杂药物地塞米松的水凝胶，然后采用界面聚合法在水凝胶中合成导电聚合物，最后通过电化学CV法刺激控制药物释放。制备了生物相容性好的导电水凝胶，同时提高了水凝胶的载药量，并提高了水凝胶的导电性，实现了药物的可控释放。63612

首先通过化学交联法制备聚乙二醇二丙烯酸酯—聚丙烯酰胺（PEGDA—PAAm）水凝胶修饰层，然后通过界面聚合法使得导电聚合物聚吡咯（PPy ）在水凝胶中聚合，则得到性能良好的导电水凝胶。然后将地塞米松磷酸钠（Dsp）掺杂到导电水凝胶中，通过CV扫描刺激Dsp的可控释放，并借助紫外可见分光光度计观察不同扫描圈数下的Dsp在磷酸盐缓冲液（PBS）中的释放情况，分析了各阶段释药量之间的关系。实验结果表明，我们得到了性能良好的药物释放体系。

毕业论文关键词：聚吡咯，导电水凝胶，药物释放

Abstract In this paper, 316L stainless steel sheet base load conductive hydrogel,doping drug dexamethasone hydrogel is first prepared, and then interfacial polymerization in an aqueous gel synthesis of a conductive polymer, and finally by the the electrochemical CV method stimulation control drug release. The biocompatible conductive hydrogel is prepared, improve the hydrogel drug loading, and to improve the conductive hydrogel, to achieve a controlled release of the drug.

Preparation of polyethylene glycol diacrylate - polyacrylamide (PEGDA-PAAm) hydrogel-modified layer by chemical crosslinking method, and then by the interfacial polymerization method such that the conductive polymer is polypyrrole (PPy) first polymerization of the hydrogel,to give a good performance of the conductive hydrogel. Dexamethasone sodium phosphate (DSP) will then be doped into the conductive hydrogels, controlled release of CV scan stimulate Dsp,and by means of UV-visible spectrophotometer observation the Dsp under different scan cycles in the release of phosphate buffered saline (PBS), and analyzes the relationship between the amounts of the various stages of drug delivery. Experimental results show that we get the good performance of the drug delivery systems.

Key words: Polypyrrole, conductive hydrogels, the drug release

第1章绪论 1

1.1导电聚合物 1

1.1.1导电聚合物的结构与性能 1

1.1.2 聚吡咯的电化学合成 1

1.2导电聚合物复合水凝胶 2

1.2.1水凝胶的结构与性能 2

1.2.2导电聚合物复合水凝胶的制备 2

1.3 水凝胶修饰电极的制备 4

1.3.1凃渍法 4

1.3.2共价键合法 5

1.3.3 电化学法 5

1.4 药物释放 5

第2章实验研究 7

2.1药品与仪器 7

2.2实验步骤 7

2.2.1 PEGDA水凝胶的制备 7

2.2.2 复合水凝胶的制备 8

2.2.3 PPy的氧化聚合 8

2.3 水凝胶的性能测试 8

2.3.1 红外光谱 8

2.3.2 溶胀动力学测试 8 316L不锈钢片导电复合水凝胶及其药物释放:http://www.751com.cn/yixue/lunwen_70219.html