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摘要本实验以聚乳酸-羟基乙酸共聚物[poly(1actide-co-glycolide) ,PLGA ]为原材料， 利用乳化-溶剂挥发法制备PLGA微球，并通过烧结技术制备PLGA微球支架，通过扫描电子显微镜对PLGA微球和烧结支架的微观结构进行观察，并对PLGA微球支架的孔隙率，力学性能等进行实验研究，探讨PLGA微球制备过程中影响微球大小的因素，近一步研究烧结时间，烧结温度等因素微球支架孔隙率，力学性能的影响。10281
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实验结果表明：（1）搅拌速度对微球大小有显著影响，当搅拌速度增加，由于溶液中剪切力的增大，乳化法得到的溶液中油相被进一步的分散，使最PLGA微球的粒径减小。（2）PLGA烧结微球支架的孔隙率和微观结构受到烧结温度和烧结时间的影响，随着烧结温度的升高，PLGA的分子链被进一步激活，相邻微球粘结程度变大，微观上PLGA微球排布更加紧密，导致孔隙率变小。同时，烧结时间对支架也相似的影响，烧结时间的增加，更有利于PLGA微球间的粘结，孔隙率也进一步减小。（3）力学测试表明，PLGA微球支架在15%的应变下应力接近1MPa, 支架材料所表现出良好的韧性和强度, 对软骨以及软骨下骨组织工程构建和细胞的植入十分有利。支架的力学性能受到烧结温度和烧结时间的影响，温度和时间的增加，使得支架中相邻微球粘结更为牢固，从而在宏观上使得支架的最大压缩强度变大。
关键词 PLGA微球 烧结时间 烧结温度 孔隙率 烧结支架
毕业设计说明书（论文）外文摘要
Title PLGA Preparation and mechanical properties of porous sintered scaffolds for tissue engineering
Abstract
In this study,PLGA [poly(1actide-co-glycolide)] is the raw material.The use of emulsion-solvent evaporation preparation of microspheres. And preparation of PLGA microspheres by sintering bracket. PLGA microspheres, and the microstructure of the sintered scaffold were observed by scanning electron microscopy, and PLGA microspheres scaffold porosity, mechanical properties, such as the experimental study to examine the factors that influence the size of the microspheres in the preparation of PLGA microspheres, taking a step forward sintering time, sintering temperature and other factors microsphere scaffold porosity, mechanical properties.
Experimental results show that :(1)Stirring speed on the size of the microspheres impact, when the stirring speed increases, the shear force in the solution increases, the solution of the emulsion oil phase dispersion, so that the most PLGA microspheres particle size decreases.(2)The PLGA sintered microsphere scaffold porosity and microstructure of the sintering temperature and sintering time, With the sintering temperature, the molecular chains of PLGA were further activate adjacent microsphere bonding larger in the micro PLGA microspheresball arrangement more closely, resulting in smaller porosity. At the same time, the sintering time is also similar to the stent, the increase of the sintering time is more conducive to bonding between the PLGA microspheres, the porosity is further reduced.(3)Mechanical testing of PLGA microspheres stents in 15% of the strain under stress close 1MPa, the scaffolds showed good toughness and strength, build cartilage and subchondral bone tissue engineering and cell implantation is very beneficial. The mechanical properties of the stent by the sintering temperature and sintering time, temperature and time increase, making the bracket adjacent microspheres bonded more firmly bracket the maximum compressive strength is larger, which makes the macro.
Keywords: PLGA Microspheres, Sintering time, Poly(lactide-co-glycolide), Sintering , Scaffold, Porosity, Sintered bracket
目 次
1 绪论 1
1.1 PLGA组织工程支架 1
1.2 PLGA组织工程支架性能 3
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