PVA水凝胶关节软骨修复材料的改性及力学性能的研究

摘要聚乙烯醇（PVA）水凝胶作为关节软骨修复材料在医学临床应用中具有很好的前景。但普通PVA 水凝胶较差的机械性能极大地限制了它的应用。本文采用冷冻-解冻循环法并改性得到多种复合水凝胶，并初步研究了它们的力学性能。主要内容与结果如下：
1.采用冷冻解冻并改性得到PVA/PVP、PVA/PAAm、PVA-C12、PVA/GO等多种复合水凝胶软骨修复材料，并初步研究了它们力学性能并进行对比；33544
2.PVA基复合水凝胶压缩应力-应变都呈现非线性关系；动态力学特性均与天然软骨相似，PVA基水凝胶是一种很有应用前景的关节软骨材料。
关键词关节软骨修复材料 PVA基复合水凝胶力学性能

毕业设计说明书外文摘要
Title    Research and mechanical properties of modified PVA   hydrogel material articular cartilage repair
Abstract
Polyvinyl alcohol (PVA) hydrogel is a hydrogel not only with normal gel performance, but with low toxicity and good mechanical properties, high water absorption and the advantages of good biocompatibility. It’s a promising artificial cartilage repairing material. The PVA based gel composite was prepared combining the Modified methods. The mechanical properties of gel composite were systemically studied. The main contents are as follows:
1.The PVA/PVP 、PVA/PAAM、PVA/GO、PVA/C12 gel composite prepared by a combination of modified methods， the effect of different parameters on the mechanical properties of PVA composite hydrogel was studied.
2. PVA based hydrogels compressive stress - strain shows a typical nonlinear relationship; compression modulus are increased with the increase of the strain, and their dynamic mechanical properties of natural cartilage is similar, indicating that PVA hydrogel is a kind of material to the articular cartilage of the application foreground.
Keywords articular cartilage repairing material PVA based hydrogels mechanical property
目次
1 绪论    1
1.1 引言    1
1.2 关节软骨的组织学特点    1
1.2.1 关节软骨的结构    1
1.2.2 关节软骨的力学性能    2
1.3 关节软骨修复材料    2
1.3.1 PVA水凝胶软骨修复材料    2
1.4 本文的研究内容及意义    4
2 PVA/PVP的制备和性能初步研究    5
2.1 引言    5
2.2 实验过程    5
2.2.1 PVA/PVP复合水凝胶的制备    5
2.2.2 PVA/PVP复合水凝胶的制备原理    5
2.3 PVA/PVP复合水凝胶的压缩和动态力学测试    6
2.3.1压缩力学性能测试    6
2.3.2 动态力学性能测试    6
2.4 结果与讨论    7
2.4.1 复合水凝胶的压缩应力-应变特性    7
2.4.2复合水凝胶的模量    7
2.4.3测试频率对其动态模量的影响    9
2.5 本章小结    10
3 PVA/GO、PVA/C12复合水凝胶力学性能的初步研究    11
3.1 引言    11
3.2 试样的制备    11
3.2.1 PVA/GO复合水凝胶的制备    11
3.2.2 PVA/C12复合水凝胶的制备    11
3.3 压缩性能和动态力学性能研究    11
3.3.1 压缩性能测试    12
3.3.2 动态力学性能测试    12 PVA水凝胶关节软骨修复材料的改性及力学性能的研究:http://www.751com.cn/cailiao/lunwen_30703.html