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摘要: 采用复凝聚法以壳聚糖为壁材来制备抗坏血酸微胶囊。本课题主要通过单因素实验来优化实验方案，探究微胶囊的包覆效果及其性能，确定各材料的用量比例，制备出包覆率高的，包覆效果好的Vc微胶囊。分别考察Vc水溶液与油相的体积比，乳化剂用量和固化剂种类等因素对微胶囊微观形貌和包覆率的影响。当Vc水溶液与油相的体积比为1:1，乳化剂用量为0.6%，内乳液与壳聚糖溶液的质量比为1:8，水相乳化剂用量为4%，固化剂与壳聚糖质量比1:5，固化剂种类为氯化钙时，Vc的包覆效果最好，性能最优。红外光谱和热重分析表明Vc微胶囊已包覆成功。并且Vc微胶囊在水中和模拟胃液中表现出良好的缓释性。43255
毕业论文关键词：复凝聚法；壳聚糖；Vc；微胶囊；双重乳液
The preparation of a slow-releasing potential antioxidant
Abstract：The objective of the present study was to improve AA microencapsulation by complex coacervation using chitosan as encapsulating agents. The optimum preparation conditions were obtained by aqueous solution than with the quality of the oil phase, emulsifier mass ratio of oil phase, type of curing agent and other single factors. The morphology of the freeze-dried microcapsules was analyzed by optical microscopy and the embedding rate was determined by UV. The optimum preparation conditions were determined: m(water solution): m(soybean oil)=1:1; m(inner emulsifier: oil phase) is 0.6%; m(inner emulsion) : m(chitosan liquid)=1:8; m(outer emulsifier: inner emulsion and chitosan liquid) is 4%,m(curing agent: chitosan liquid) =1:5, using CaCl2 as curing agent. Vc microcapsules has slow-releasing potential in water and simulated gastric juice. By thermogravimetric analysis shows that the Vc microcapsule coated successfully.Vc microcapsules determined by FTIR spectrometer. The emergence of Vc characteristic functional groups of absorption peak shows that the Vc microcapsule coated successfully.
Keywords: Complex coacervation; Chitosan; Vitamin C; Microcapsule; Double emulsio
目录
1.1 微胶囊的概念 1
1.2 微胶囊的用途 1
1.3 微胶囊的制备方法 2
1.3.1 喷雾干燥法 2
1.3.2水浴干燥法 3
1.3.3相分离法 3
1.4 微胶囊壁材的选择 4
1.5.1 VC的性质 5
1.5.2 V c应用中所面临的问题 5
1.5.3 V c微胶囊的研究 5
1.6 本课题的研究目的和意义 6
2实验部分 7
2.1 实验材料试剂和仪器设备 7
2.1.1 实验材料试剂 7
2.1.2 主要仪器和设备 7
2.2 VC微胶囊的制备 8
2.2.3 探究单因素实验优化 8
2.3 VC微胶囊的性能表征 8
2.3.1 光学显微镜 9
2.3.2 紫外分光光度法测定微胶囊包埋率 9
2.3.3 紫外分光光度法缓释性测试