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摘要：本文中，我们对介孔二氧化硅进行了表面修饰，即在其表面包覆一层壳聚糖层，制备得到具有pH响应的介孔二氧化硅/壳聚糖复合微球。根据SEM的表征证实了MSN具有单一有序的介孔结构。表面Zeta电位和接触角实验表明，CS修饰后的MSN微球表面电荷增加，亲水性亦增加。氮吸附BET结果显示，随着CS含量的增加，MSN微球具有更加丰富的孔道及更小的孔径。此外，本课题以阿霉素（DOX）为模型药物，研究所制备的复合微球的释药行为。结果显示，所合成的复合微球具有pH响应的药物释放行为,与pH值等于7.4时相比，在较低的pH值（5.5）时，药物释放的速率明显加快。43781
毕业论文关键词：介孔二氧化硅；纳米药物载体；纳米药物输送系统；壳聚糖；壳聚糖表面修饰
The Researches on the Preparation and Properties of Drug loaded Mesoporous/Chitosan silica microspheres
Abstract : In this paper, the pH sensitive mesoporou silica was fabricated with a chitosan (CS) layer on the surface. According to the characterization of SEM, it was proved that MSN has a single ordered mesoporous structure. The surface Zeta potential and contact angle test showed that the surface charge of MSN particles was increased and the hydrophilicity was increased after being coated by CS. Nitrogen adsorption (BET) results showed that with the increase of CS content, MSN microspheres had more pore quantity and smaller pore size. In addition, the drug release behavior of the composite microspheres was studied with adriamycin (DOX) as a model drug. The results showed that the composite microspheres had the pH dependent, while the release rate at pH 5.5 was much faster than that of pH 7.4.
Keywords：Mesoporous Silica; Nano Drug Carrier; Nano Drug Delivery System; Chitosan; Chitosan surface modification
目 录
1.1 引言 1
1.2 纳米药物运输体系 1
1.3 纳米药物载体的优势 3
1.4 介孔二氧化硅纳米颗粒 4
1.4.1 介孔二氧化硅纳米材料的合成机理 4
1.4.2 介孔二氧化硅制备工艺的研究进展 5
1.5 介孔二氧化硅纳米材料的功能化 6
1.5.1 介孔二氧化硅纳米材料的单一功能化 7
1.5.2 介孔二氧化硅纳米材料的多功能化 7
1.5.3 介孔二氧化硅纳米材料的实际应用 7
1.6 本课题研究的目的和意义 8
2 实验部分 9
2.1 试剂和设备 9
2.2 实验方法 10
2.2.1 介孔二氧化硅微球（MSNs）合成 10
2.2.2 壳聚糖修饰介孔二氧化硅 10
2.2.3 MSNs/CS载药性能的研究 10
2.3 测试与表征 11
2.3.1 MSNs的基础理化性能表征